1997 Volume 61 Issue 1 Pages 199-201
Human urokinase (UK) was easily degraded during the incubation at 37°C in a time-dependent manner. The degradation was also observed in the presence of trypsin inhibitors, suggesting that UK was not degraded by exogeneous trypsin-like serine protease but by autolysis. In this cases, the A-chain of UK was selectively degraded. Polyethylene glycol-polypropylene glycol conjugated urokinase (PEG-PPG-UK) was not degraded after prolonged incubation at 37°C. These results demonstrated that PEG-PPG modification completely blocked the degradation of UK by autolysis.
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