Carquinostatin B, a New Neuronal Cell-protecting Substance Produced by Streptomyces exfoliatus

Kazuo SHIN-YA; Toshihiro KUNIGAMI; Jun-Sik KIM; Kazuo FURIHATA; Yoichi HAYAKAWA; Haruo SETO

doi:10.1271/bbb.61.1768

Kazuo SHIN-YA, Toshihiro KUNIGAMI, Jun-Sik KIM, Kazuo FURIHATA, Yoichi HAYAKAWA, Haruo SETO

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Keywords: ischemia injury, L-glutamate toxicity, neuroprotection, carquinostatin B, antioxidative substance

JOURNAL FREE ACCESS

1997 Volume 61 Issue 10 Pages 1768-1769

DOI https://doi.org/10.1271/bbb.61.1768

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Abstract

Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.

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