1997 Volume 61 Issue 11 Pages 1960-1962
The staphylococcal Panton-Valentine leukocidin (PVL) genes [luk-S-PV-lukF-PV] existed in a hexagonal phage-like particle (φPVL) isolated from mitomycin C-induced Staphylococcus aureus V8 (ATCC 49775). The genome packed in φPVL was a linear double-stranded 40-kb DNA with single-stranded cohesive ends (cos). The [lukS-P V-lukS-PV], attP, and int (integrase gene) of φPVL were all located very close to one another within a 4.0kb-segment on the genome in the order given, and the segment is located at the center from the left and the right cos sites. In addition, the [lukS-P V-lukF-PV]-attP-int region contains 5 direct repeat sequences that show high similarity with the recombinase-binding sites of bacteriophages of S. aureus.
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