Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Effects of a Hydrogenated Isomaltooligosaccharide Mixture on Glucan Synthesis and on Caries Development in Rats
Jun TSUNEHIROTakashi MATSUKUBOMasao SHIOTAYoshinori TAKAESU
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1997 Volume 61 Issue 12 Pages 2015-2018

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Abstract

The caries inhibitory effect of the hydrogenated derivative of an isomaltooligosaccharides mixture (IMO-H) was examined in vitro and in vivo experiments. IMO-H could not be used as a substrate for the crude glucosyltransferases (GTases) of Streptococcus sobrinus 6715 to synthesize water-insoluble glucan. Moreover, it not only significantly inhibited the synthesis of water-insoluble glucan from sucrose, but also the sucrose-dependent adherence of these growing cells the glass surfaces. In the in vivo experiment, the addition of IMO-H to a sucrose-containing diet resulted in significant reduction of caries development in specific-pathogen-free (SPF) rats infected with S. sobrinus 6715.

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