Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Total Synthesis of (+)-Phrymarolin I from (+)-Malic Acid
Momotoshi OKAZAKIFumito ISHIBASHIYoshihiro SHUTOEiji TANIGUCHI
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JOURNAL FREE ACCESS

1997 Volume 61 Issue 4 Pages 660-663

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Abstract

(+)-Phrymarolin I was stereoselectively synthesized from (R)-(+)-3-hydroxybutanolide that had been prepared from (+)-malic acid. The procedure is more efficient than our previous synthesis in terms of fewer reaction steps and the easier availability of the starting material.

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