Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
A Water-Soluble Spin Probe Newly Developed for Liposomal Studies
Junzo SunamotoKazunari AkiyoshiTetsuji KiharaMasayuki Endo
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1992 Volume 65 Issue 4 Pages 1041-1046

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Abstract

A water-soluble spin probe, disodium 4-[(4,8-sulfonatooxy-2-naphthyl)thioureylene]-2,2,6,6-tetramethyl-1-piperidinyloxyl (TEMPO-T) was newly synthesized and characterized comparing with several different TEMPO derivatives from the view point of a possibility of utilization in the liposomal studies. Of TEMPO derivatives studied, TEMPO-T was the best probe because of the high water solubility, the less lipophilicity, the less leakiness from liposome, and the reliable stability to both temperature and pH changes.

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© 1992 The Chemical Society of Japan
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