1998 Volume 71 Issue 6 Pages 1355-1362
New organotin(IV) complexes of the general formula R3SnL [where R = Me, Bu, and Ph], Ph2SnL2 and Bu2SnL2 [where L = monoanion of DL-methionine (HL-1) and L-asparagine (HL-2)] were synthesized and characterized by elemental analyses as well as molar conductance, electronic, infrared, far-infrared, 1H and 13C NMR, and 119Sn Mössbauer spectral studies. Probable structures are suggested for the complexes. Thermal studies of a few complexes have been carried out in the temperature range 25—1000 °C using the TG, DTG, and DTA techniques, indicating the formation of SnO as a residue. The complexes were tested in vitro against a wide spectrum of bacteria and fungi and found to be active. Only two complexes, Ph3SnL-1 and Ph3SnL-2, have been found to be slightly active in vivo against a multiinfection fungal model in mice.
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