Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Organic and Biological
An Effective System to Synthesize Hypolipidemic Active α-Asarone and Related Methoxylated (E)-Arylalkenes
Anuj SharmaBhupendra P. JoshiArun K. Sinha
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2004 Volume 77 Issue 12 Pages 2231-2235

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Abstract

Methoxylated (E)-arylalkenes (1a1k) were prepared in two steps by an improved Grignard reaction comprising the reverse addition of alkylmagnesium bromide to benzaldehydes (2a2k) in anhydrous ether and toluene into arylalkanols (3a3k) in high yield, followed by dehydration with silica gel under microwave irradiation for 3–12 min, depending upon the substituents attached to the aromatic ring to afford hypolipidemic active α-asarone (1a) and related methoxylated (E)-arylalkenes (1b1k).

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© 2004 The Chemical Society of Japan
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