Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Formation of Pyrene Dimer Radical Cation at the Minor Groove of DNA
Kiyohiko KawaiTakumi KimuraHiroko YoshidaAkira SugimotoSachiko TojoMamoru FujitsukaTetsuro Majima
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2006 Volume 79 Issue 2 Pages 312-316


To arrange pyrene at the minor groove of DNA, we synthesized a nucleoside derivative possessing a pyrene group on guanine N2. Doubly pyrene-modified duplex DNA was synthesized and the formation rates of the pyrene dimer radical cation were measured upon one-electron oxidation during pulse radiolysis. For all of the DNA studied here, the formation of a pyrene dimer radical cation was accomplished quickly, within 20 micro seconds after a 8-ns electron pulse during pulse radiolysis. The results show that the minor groove of DNA offers a good space for the formation of pyrene dimer radical cations.

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© 2006 The Chemical Society of Japan
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