Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
The Chemical Society of Japan Award for Creative Work for 2012
Development of Direct Aromatic Coupling Reactions by Transition-Metal Catalysis
Masahiro MiuraTetsuya SatohKoji Hirano
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2014 Volume 87 Issue 7 Pages 751-764

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Abstract

Transition-metal-catalyzed aromatic cross-coupling reactions are highly useful for constructing various organic fine chemicals. The conventional methods, however, usually require the preactivation of aromatic substrates such as stoichiometric halogenation and metalation before the coupling event, which increases the steps leading to target molecules and yields inevitable salts as by-products. In order to cope with these problems, catalytic C–H transformation reactions on aromatic substrates have been one of the most intensive subjects in the area of catalytic organic synthesis. Summarized herein are our efforts for developing direct aromatic and heteroaromatic coupling reactions by using a number of transition metals as catalysts.

Transition-metal-catalyzed direct aromatic coupling reactions as the complementary methods of conventional cross-couplings have recently been significantly developed. Our efforts in the research area are summarized in this account. Fullsize Image
 
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© 2014 The Chemical Society of Japan
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