Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
 
Bisoxazoline-Catalyzed Asymmetric Nucleophilic Addition of Diethyl Zinc to Fluorinated Alkyl Ketones: Enantiofacial Control by Changing the Bisoxazoline Substituent
Shigeru SasakiTakayasu YamauchiMasatomi KanaiAkihiro IshiiKimio Higashiyama
Author information
JOURNAL RESTRICTED ACCESS

2015 Volume 88 Issue 1 Pages 200-208

Details
Abstract

Bisoxazoline (BOX)-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcohols. The effect of the size of the substituent on the oxazoline ring on the stereoselectivity of the reaction was investigated. Furthermore, the enantioselectivity could be reversed by altering the BOX bridge structure while retaining the C-4 substituent on the oxazoline ring.

Content from these authors

This article cannot obtain the latest cited-by information.

© 2015 The Chemical Society of Japan
Previous article Next article
feedback
Top