Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
The Chemical Society of Japan Award for Creative Work for 2016
A Bioorganic Chemistry Approach to Understanding Molecular Recognition in Protein–Nucleic Acid Complexes
Takashi Morii
Author information
JOURNALS RESTRICTED ACCESS

2017 Volume 90 Issue 12 Pages 1309-1317

Details
Abstract

A combination of synthetic, organic, and biochemical approaches has been developed to study how protein and nucleic acid assemblies modulate the affinity, specificity and cooperativity of protein–nucleic acid interactions. These strategies have enabled formation of noncovalent peptide dimers on specific DNA sequences. A new framework from RNA and peptide into a stable complex of ribonucleopeptide was also developed to construct receptors and fluorescent sensors for small molecules. Attempts to design novel DNA-binding peptides, receptors and sensors will provide an ultimate test for our understanding of the principle of molecular recognition associated with protein–nucleic acid interactions.

A combination of synthetic, organic, and biochemical approaches has been developed to study the specific and cooperative formation of assemblies by proteins and nucleic acids. These strategies enabled recognition of specific DNA sequences by peptide dimers and construction of receptors and the fluorescent sensors by a stable complex of ribonucleopeptide. Fullsize Image
 
Information related to the author

This article cannot obtain the latest cited-by information.

© 2017 The Chemical Society of Japan
Previous article Next article
feedback
Top