2017 Volume 90 Issue 12 Pages 1309-1317
A combination of synthetic, organic, and biochemical approaches has been developed to study how protein and nucleic acid assemblies modulate the affinity, specificity and cooperativity of protein–nucleic acid interactions. These strategies have enabled formation of noncovalent peptide dimers on specific DNA sequences. A new framework from RNA and peptide into a stable complex of ribonucleopeptide was also developed to construct receptors and fluorescent sensors for small molecules. Attempts to design novel DNA-binding peptides, receptors and sensors will provide an ultimate test for our understanding of the principle of molecular recognition associated with protein–nucleic acid interactions.
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