Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
The Chemical Society of Japan Award for Young Chemists for 2016
Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products
Yuki GotoHiroaki Suga
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2018 Volume 91 Issue 3 Pages 410-419

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Abstract

Recent advances in genome databases have allowed discovery of novel classes of natural products and their biosynthetic enzymes. Given the potentials and advantages of the biosynthetic enzymes, they are applicable to not only the production of natural products but also synthesis and discovery of artificial molecules with desired functions. This account describes our recent efforts to develop artificial in vitro biosynthesis systems that potentially allow for the elaboration of pseudo-natural peptides with novel bioactivities.

Recent advances in genome database has allowed discovery of novel classes of natural products and their biosynthetic enzymes. Given the potentials and advantages of the biosynthetic enzymes, they are applicable to not only the production of natural products but also synthesis and discovery of artificial molecules with desired functions. This account describes our recent efforts to develop artificial in vitro biosynthesis systems that potentially allow for the elaboration of pseudo-natural peptides with novel bioactivities. Fullsize Image
 
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