Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Ion-selective Electrodes Sensitive to Some Organic Compounds Used as Drugs
Kenyu KinaNobuko MaekawaNobuhiko Ishibashi
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1973 Volume 46 Issue 9 Pages 2772-2773


Drug ion-selective electrodes with a liquid membrane have been developed which are sensitive to methacholine, neostigmine, N-1-methyl nicotinamide, diphenhydramine, vitamin B1, vitamin B6, p-aminosalicylic acid (PAS), and salicylic acid. Crystal violet or ferroin-compound cations and dipicrylamine or tetraphenylborate anions were used as the ion-exchange sites in the liquid membrane. Each liquid membrane was prepared by using the solvent-extraction method and exhibited an appropriate Nernstian response to the respective ion down to 10−4 or to 10−5 M. The electrode performances, including the selectivity coefficients, are summarized in Table 1.

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