Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Synthesis of Protected Peptide Fragments Related to Porcine Motilin
Shigeru MiharaFumio ShimizuSeiji Miyamoto
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1976 Volume 49 Issue 12 Pages 3589-3593

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Abstract

Syntheses are described of three protected peptide fragments which correspond to positions 1–6, 7–11, and 12–22, respectively, of the entire amino acid sequence of porcine motilin, a gastric motoractivity-promoting polypeptide. Stable tosyl group was used for the protection of ε-amino group of lysine and guanidino group of arginine. These protected peptide fragments were mainly constructed in step wise manner using benzyloxycarbonyl amino acid by mixed anhydride method in the presence of N-hydroxysuccinimide. For preparation of the C-terminal undecapeptide, fragment condensation method was employed using two protected tripeptide azides. The protected peptides and intermediates could be readily purified by simple procedure.

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