Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Conformational Study of Glutathione by NMR
Shizuo FujiwaraGrazyna Formicka-KozlowskaHenryk Kozlowski
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1977 Volume 50 Issue 12 Pages 3131-3135


Proton NMR spectra of glutathione have been analyzed over the whole pH region. The spectra of the glutamic acid residue are of the ABCDX type at pHs below 2.5, of the AA′BB′X types in the pH region 2.5–9, and of the ABCC′X type at pHs higher than 9. For the cysteine part, spectra of the ABC type have been observed at pHs higher than 8, which change to spectra of the A2B type at pHs lower than 7. On the basis of these results the conformation of the glutathione molecule in solution has been discussed in detail.

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