1983 Volume 56 Issue 12 Pages 3657-3660
A new type of cationic polynucleotide analog binding RNase A and its related compounds were synthesized from an insoluble cross-linked poly(4-vinylpyridine). The cross-linked poly(4-vinylpyridine) was converted into an aldehyde derivative by the reaction with cyanogen bromide. The aldehyde derivative was used for the binding of RNase A and 9-(2-aminoethyl)adenine through their amino groups. The cationic adenine polynuleotide analog binding RNase A favorably interacted with nucleotides containing uracil base through the base-specific interactions. This analog showed the considerable selectivity in the hydrolysis of uridine polynucleotide owing to the template effect.
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