1983 Volume 56 Issue 12 Pages 3672-3678
The present study deals with Mg-catalyzed asymmetric reduction of ethyl benzoylformate by the use of C2-symmetric NADH model compounds in which axial dissymmetry (chiral 1, 1′-binaphthyl derivatives) was introduced as a chiral source for the first time and the results were compared with those obtained by the corresponding C1-symmetric models bearing the same chiral center. Better e.e.’s of the reduction product were obtained by the use of NADH models having C2-symmetry than does the corresponding C1 symmetric ones. Further, the kind of bonding as well as the distance between chiral binaphthyl and the reaction center affected the stereochemical course of hydrogen transfer.
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