Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Penetration of Lysine–Leucine Copolymers into Lecithin Monolayers from Underlying Aqueous Solutions
Masayuki NakagakiEmiko OkamuraShigeo Kubota
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1983 Volume 56 Issue 12 Pages 3730-3734


The penetration of water soluble polymers into lecithin monolayers was investigated for the random copolymers of L-lysine and L-leucine at various compositions in order to discuss the effect of hydrophobicity and charge density of the copolymers on their interaction with lipid monolayers. Compared to the penetration of the amino acids(L-lysine and L-leucine), the copolymer penetrated at very low concentration whereas the monomer (amino acid) did not. The amount of copolymer penetration increased significantly when the leucine fraction of a copolymer, XLeu, was larger than 0.3, while little penetration occurred when XLeu was smaller than 0.25. From these facts, it has been concluded that the penetration of lysine–leucine copolymers was not only attributed to the hydrophobicity or the charge density of copolymer molecules, but also to specific surface effects such as (1) the enhanced penetration of macromolecules by the preceded penetration of polymer segments of the same molecule, or (2) the formation of a compact α-helical structure as the result of the restricted motion of the segment near the lipid surface.

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