Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Enantiodivergent Total Syntheses of Nanaomycins and Their Enantiomers, Kalafungins
Kuniaki TatsutaKohji AkimotoMasahiko AnnakaYutaka OhnoMitsuhiro Kinoshita
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1985 Volume 58 Issue 6 Pages 1699-1706

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Abstract

The first, enantiospecific total syntheses of pyranonaphthoquinone antibiotics, nanaomycins D and A, and their enantiomers, kalafungin and 4-deoxykalafunginic acid are described by an “enantiodivergent” strategy from a common optically active intermediate, (1S,3RS,4S)-3,4-dihydro-5,9,10-trimethoxy-1-methyl-1H-naphtho[2,3-c]pyran-3,4-diol, which has been derived from L-rhamnose via condensation of 4-methoxy-3(phenylsulfonyl)-1(3H)-isobenzofuranone and methyl 3,4,6-trideoxy-α-L-glycero-hex-3-enopyranosid-2-ulose.

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