Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Oxidation of Lipids, XII. Inhibition of Oxidation of Soybean Phosphatidylcholine and Methyl Linoleate in Aqueous Dispersions by Uric Acid
Etsuo NikiMitsuo SaitoYasuyuki YoshikawaYorihiro YamamotoYoshio Kamiya
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1986 Volume 59 Issue 2 Pages 471-477

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Abstract

The activity of uric acid as a chain-breaking antioxidant was studied in the oxidations of methyl linoleate micelles and soybean phosphatidylcholine liposomes in aqueous dispersions at 37°C. Uric acid was found to act as a radical scavenger. Uric acid located in an aqueous phase could trap the radicals in an aqueous phase, but it could not scavenge radicals within the lipid region of micelles and liposomal membranes. The kinetics of the oxidations of lipids in aqueous dispersions inhibited by uric acid was discussed.

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