Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Studies on β-Turn of Peptides. XII. Synthetic Confirmation of Weak Activity of [D-Pro5,5′]-Gramicidin S Predicted from β-Turn Preference of Its Partial Sequence
Kazuki SatoRika KatoUkon Nagai
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1986 Volume 59 Issue 2 Pages 535-538

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Abstract

[D-Pro5,5′]-Gramicidin S was synthesized to confirm a prediction that D-D sequence at the corner position had low preference for β-turn. The analog showed much weaker activity than gramicidin S and also showed different CD spectra from those of gramicidin S. The results indicate that the analog can not take stable, gramicidin S-like, β-sheet conformation.

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