Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Effects of Bivalent Metal Cations on the Conformation and Aggregation of Poly(L-glutamic acid)
Hiroshi MaedaTsuyoshi HiramatsuShoichi Ikeda
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1986 Volume 59 Issue 2 Pages 587-591

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Abstract

In the solution of fully neutralized poly(L-glutamic acid) in the absence of supporting electrolytes, the α-helix was induced by the addition of five transition metal chlorides in the following order: CuCl2\gtrsimCdCl2>ZnCl2>NiCl2>CoCl2. The induction did not occur by the addition of BaCl2, CaCl2, or MgCl2. The induction by transition metal cations was inhibited in the presence of a supporting electrolyte (NaCl). Distortion of circular dichroism (CD) spectra occurred as the induction of the α-helix proceeded, which was shown to be recognizable when apparent aggregation number m exceeded about 100. Conformation of the polypeptide in these aggregates was expected to be the α-helix based on the conformation in the precipitates obtained at these mixing ratios which gave distorted CD spectra, which was determined by infrared absorption spectra.

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