Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
Synthesis of 7-Substituted 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-ones. Reaction of 7-Hydroxy Derivatives with Nucleophiles
Takehiko GotoShin UtsunomiyaHiroshi AibaHirotaka HayasakaMikihiro EndoReo WatanabeTakeshi IshizakiRyu SatoMinoru Saito
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1991 Volume 64 Issue 6 Pages 1901-1910

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Abstract

Various 7-substituted 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ones are synthesized by the reaction of the corresponding 7-hydroxy derivatives with nucleophiles involving active methylene compounds, aromatics, alcohols, p-toluenethiol, benzenesulfinic acid, triethyl phosphite, ammonia, and amines under acidic or basic conditions. Some synthetic applications of the products obtained are demonstrated to give a 7-methylene derivative and fused tricyclic derivatives.

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