The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
Human cDNA Encoding a Novel TGF-β Superfamily Protein Highly Expressed in Placenta
Midori Yokoyama-KobayashiMihoro SaekiShingo SekineSeishi Kato
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1997 Volume 122 Issue 3 Pages 622-626


Recently, we developed a simple method for detecting a secretory signal sequence encoded by a cDNA fragment. In this study, we used this method to select cDNA clones encoding secretory proteins from a human full-length cDNA library. Full-sequencing analysis of the candidate clones revealed that one clone encoded a novel TGF-β superfamily protein. The clone encodes a protein of 308 amino acids of which the C-terminal region shows a characteristic feature of TGF-β superfamily proteins: seven conserved cysteine residues at the C-terminal preceded by a putative processing site composed of a basic amino acid repeat. The corresponding transcripts are highly expressed in the placenta, so the novel protein may play an important role in reproduction.

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© The Japanese Biochemical Society
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