GLUCOSE METABOLISM AND AMINO ACID IN BRAIN SLICES

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1. The distribution of C¹⁴ from uniformly labelled C¹⁴-glucose incubated aerobically with brain slices for 90 minutes was studied using the radio-paperchromatography technique.
2. Effects of various conditions and some metabolic inhibitors which change the glucose metabolism of brain slices upon the pattern of radio-autograph was investigated.
3. The formation of amino acids from plucose was clearly inhibited by metabolic inhibitors of the glycolytic route and the citric acid cycle.
4. Glutamic acid was thought to function possibly as a connecting gate between glucose metabolism and amino acids in brain tissue.