Effect of Triton WR-1339 on the Rates of Synthesis and Degradation of Hepatic Catalase of Rat

抄録

The effect of Triton WR-1339 on the rates of synthesis and degradation of hepatic catalase was examined. Triton WR-1339 was injected intraperitoneally into rats at a dose of 200mg per 100g body weight. Catalase activity decreased to about 35 % of that of the control at 42-48h after the injection and recovered to the normal level at 96 h. Other peroxisomal enzymes, D-amino acid oxidase and urate oxidase, showed similar patterns of the activities to those of catalase. During the first 48 h after the injection of Triton WR-1339, the rate of catalase synthesis (k_s) fell to below a detectable value, while that of the degradation (k_d) did not show any significant change. On the other hand, during the period 48-96h after the injection, the rate of the synthesis (k_s) returned to the normal level though that of the degra-dation (k_d) decreased to about 50% of the control.