Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
ISSN-L : 0388-6107
Full Papers
Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates applied to bone defects of rat calvariae
Taku KOJIMAPaulo H L FREITASSobhan UBAIDUSAkiko SUZUKIMinqi LIMichiko YOSHIZAWAKimimitsu ODATakeyasu MAEDAAkira KUDOChikara SAITONorio AMIZUKA
著者情報
ジャーナル フリー

2007 年 28 巻 4 号 p. 219-229

詳細
抄録

We aimed to histologically elucidate whether bioresorbable plates (DeltaSystem®) can induce cortical bone formation, which is essential for long-lasting bone augmentation. Standardized bone defects in rat calvariae were covered with a convexly-shaped DeltaSystem® plate, and then processed for histological observations. At 1 week, alkaline phosphatase-positive osteoblasts were seen in the newly-formed bone extending from the cavity's bottom, indicating accelerated osteogenesis. A thick layer of soft connective tissue positive for periostin, a hallmark of periosteum, covered this new bone. At 2 weeks, a spongy bone had filled the cavity up to half its height. The inner layer of the soft tissue facing the spongy bone revealed abundant periostin and osteopontin, and had many tartrate-resistant acid phosphatase-positive osteoclasts. At 4 weeks, this layer had given rise to thin new bony matrices without relation to the spongy bone arising from the cavity. These bone matrices had been thickened by 8 weeks, and turned into a thick cortical bone outlining the regenerated bone at 12 weeks. Thus, our study has provided histological evidences of cortical osteogenesis when DeltaSystem® plates are used for bone augmentation procedures.

著者関連情報
© 2007 Biomedical Research Press
前の記事
feedback
Top