Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
ISSN-L : 0388-6107
Full Papers
Steroid changes adipokine concentration in the blood and bone marrow fluid
Tatsuya FUKUSHIMAAkira HOZUMIMasato TOMITAAkihiko YONEKURANoriaki MIYATATakashi MIYAMOTOKenji TAGUCHIHisataka GOTOKeiichi TSUDAMakoto OSAKI
著者情報
ジャーナル フリー

2016 年 37 巻 3 号 p. 215-220

詳細
抄録

Our previous study has shown that plasminogen activator inhibitor 1 (PAI-1) gene expression and secretion from bone marrow adipocytes increased markedly with dexamethasone administration. The purpose of the present study was to measure the secretion of various adipokines from human bone marrow and blood, and investigate how adipokine secretion changes in a steroid environment. Human blood and bone marrow fluid were collected from a steroid treatment group and a control group during hip replacement surgery, and an enzyme-linked immunosorbent assay (ELISA) was used to measure the adiponectin, leptin, and PAI-1 levels. Adiponectin and leptin showed no significant differences between bone marrow and blood levels, but PAI-1 was significantly higher in bone marrow. The steroid treatment group had higher levels of leptin and PAI-1 in both the blood and bone marrow than the control group. PAI-1 was present at high concentrations in the bone marrow and increased by steroid treatment. High levels of PAI-1 in bone marrow may influence intraosseous hemodynamics and may induce necrotic bone disorders.

著者関連情報
© 2016 Biomedical Research Press
前の記事
feedback
Top