IDENTIFICATION AND DISTRIBUTION OF mRNA FOR CALCIUM-ACTIVATED NEUTRAL PROTEASE (CANP)

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Messenger RNA (mRNA) for Ca²⁺-activated neutral protease (CANP) in chicken tissues and its translation product were identified. CANP mRNA was 3.5 kilobase-long, and the molecular weight of the primary translation product was about 80,000 which was indistinguishable from that of mature CANP. The lung had the highest content of CANP mRNA, whereas its content in the liver was low. Ubiquitous occurrence of CANP mRNA in chicken tissues indicates its essential role in cellular functions.