Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
ISSN-L : 0388-6107
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TYROSINE METABOLISM IN RATS: p-HYDROXYPHENYLACETIC ACID IS SYNTHESIZED VIA p-HYDROXYPHENYLPYRUVIC ACID
MICHIO SHIMAMURATOKISHI HAYASHIHIROSHI NARUSE
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1987 年 8 巻 4 号 p. 247-251

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Deuterium-labelled p-hydroxyphenylpyruvic acid (PHPPA) was synthesized, and injected intraperitoneally to rats. Deuterium-labelled metabolites excreted into urine were analyzed by means of gas chromatography-negative ion chemical ionization mass spectrometry. During four hours after the injection, the ratio of deuterium-labelled p-hydroxyphenylacetic acid (PHPA) to non-deuterated one reached a high level. On the other hand, the ratio of labelled p-tyramine to non-labelled one remained at a low level. These results indicate that PHPA is biosynthesized not only through deamination of p-tyramine but also through oxidative decarboxylation of PHPPA.

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© 1987 Biomedical Research Press
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