A-Cell：仮想神経細胞構築のための計算機ソフトウエア

抄録

Virtual neuron is a model neuron, which is expressed by a computer-executable format. Virtual neuron comprises all biochemical, biophysical, electrical and mechanical mechanisms lying behind the phenomena of a real neuron. Here, we show A-Cell software, which was developed for modeling and simulation of virtual neuron. A model for Ca/calmodulin-dependent protein kinase II (CaMKII) activation in a spine was constructed. The simulation of the A-Cell model showed the localized distribution of activated CaMKII near PSD (postsynaptic density). This localization could be a basis for the translocation of activated CaMKII to PSD, which was observed in experiments.