生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
解説
1分子測定によるタンパク質の折りたたみ研究の展開
鎌形 清人木下 雅仁高橋 聡
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ジャーナル フリー

2009 年 49 巻 6 号 p. 282-286

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To understand the molecular mechanism of protein folding, it is necessary to reveal the dynamics of single proteins from the unfolded state to the folding transition state. We therefore developed a new system that can detect fluorescence signals from free single proteins for extended time periods. The system enabled us to characterize a slow conformational dynamics for the unfolded state of cytochrome c. Furthermore, we proposed a method to estimate the equilibration time for the intermediate state of protein folding.

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© 2009 by THE BIOPHYSICAL SOCIETY OF JAPAN
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