生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
総説
F1の化学反応スキームに関する新しい理解
渡邉 力也野地 博行
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ジャーナル フリー

2012 年 52 巻 1 号 p. 014-017

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F1-ATPase (F1) is a rotary motor protein which couples ATP hydrolysis/synthesis to rotary motion in a reversible fashion. Compared to other motor proteins, F1 is unique for its high efficiency and reversibility in converting chemical energy into mechanical work. To elucidate its marvelous mechanism, we developed the novel single-molecule manipulation technique with magnetic tweezers and determined the timing of Pi release, which was the last unknown piece of the puzzle of chemomechanical coupling scheme of F1. The established fundamental chemomechanical coupling scheme gave us a clue for high reversibility between catalysis and mechanical work.

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© 2012 by THE BIOPHYSICAL SOCIETY OF JAPAN
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