生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
細胞はどのように長さを測るか
吉川 雅英小田 賢幸柳澤 春明
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2015 年 55 巻 5 号 p. 250-254

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Existence of cellular structures with specific size and length raises a fundamental question in biology: how do cells measure length? One conceptual answer to this question is a molecular ruler, but examples of such rulers in eukaryotes have been lacking. We recently identified a molecular ruler in eukaryotic cilia and flagella using genetic screening and cryo-electron tomography. We demonstrated that FAP59 and FAP172 form a 96-nm-long complex in Chlamydomonas flagella and the absence of the complex disrupted 96-nm repeats of axonemes. Furthermore, lengthening of the FAP59/172 complex resulted in extension of the repeats up to 128 nm.

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© 2015 by THE BIOPHYSICAL SOCIETY OF JAPAN
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