生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
総説
基質の軟らかさが誘引する上皮細胞の集団運動と3次元形態形成
芳賀 永
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ジャーナル フリー

2018 年 58 巻 4 号 p. 196-199

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抄録

Collective movement and 3D morphogenesis are essential events in diverse physiological processes. We found that epithelial cells (MDCK cells) move collectively along one direction on a soft collagen gel, whereas the cells migrate randomly on a rigid collagen-coated-glass. Moreover, lumen formation occurred when an epithelial sheet on a collagen gel was overlaid with another collagen gel. We also found that MDCK cells formed 3D morphology on top of the Matrigel. The appearance of the morphologies was like a tulip hat. The cells tugged at the peripheral matrix and remodeled the gel surface. In this mini-review, these dynamical behaviors of the epithelial cells are discussed in terms of the cellular contractile force and viscoelasticity of the extracellular matrix.

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© 2018 by THE BIOPHYSICAL SOCIETY OF JAPAN
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