微量クロマチン蛋白質の精製と性質

抄録

We have surveyed chromatin proteins from the liver of egg-laying hens and the transformed rat cells in an attempt to find the factors presumed to be involved in determinating tissue-specific and transformation-specific expression of the genes. A non-histone chromatin protein with a molecular weight of 10, 000 daltons was purified from the liver of egg-laying hens. The VS protein binds tightly to hen genomic DNA fragments carrying at least a part of the vitellogenin structural gene. A specific non-histone chromatin protein with a molecular weight of 38, 000 daltons, 38K protein, was purified as a pure state from the transformed rat cells.