生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
ハチ毒MCDペプチドによるシナプス伝達効率長期増強作用
池中 一裕近藤 哲朗藤本 一朗相本 三郎北条 裕信御子柴 克彦加藤 宏司伊藤 憲一
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1990 年 30 巻 1 号 p. 22-27

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A bee venom, mast cell degranulating peptide (MCD), was synthesized by stepwise formation of the two distinct disulfide bridges. This synthetic peptides with mast cell degrahulating activity MCD induced long-term potentiation (LTP) in the CAl region of hippocampus, while other peptides with mast cell degranulating activity apamin and mastoparan did not. This and other results using derivatives of the synthetic MCD suggest that a rigid structure is required for the LTP induction by MCD. Two antagonists of the N-methyl-D-aspartate (NMDA) receptor, AP5 and MK801, did not block the MCD induced-LTP. Moreover, the efficacy of the synaptic transmission in the slice which had been maximally activated by tetanic stimulation was further potentiated by MCD treatment. These results indicate that two quite distinct pathways for LTP formation exist in the CAl region of the hippocampus.

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© by THE BIOPHYSICAL SOCIETY OF JAPAN
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