Various improvements have been brought into X-ray solution scattering by the use of synchrotron radiation: time-resolved solution X-ray scattering became feasible; the application of solution scattering have been extended to non-native conformations of proteins. SPring-8 will brings the further improvements: to carry out experiments in very short times; to obtain very accurate data from very low angle to quite high angle. These factors should change the quality of investigation. The combined use of solution scattering with SPring-8 and molecular dynamics simulation will open the way to deduce solution structures and/or structural changes upon ligand binding based on crystal structures. Elucidation of the folding mechanism through the structure of non-native conformations are also expected. We will be able to carry out single-shot time-resolved measurements of msec time resolution at SPring-8 with a new high sensitive detector.