生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
ロドプシンのリン酸化と脱リン酸化の分子メカニズム
大黒 浩
著者情報
ジャーナル フリー

1997 年 37 巻 4 号 p. 155-160

詳細
抄録

Rhodopsin absorbs light and undergoes a photobleaching. Its intermediates activate a cGMP cascade that generates a hyperpolarized potential in rod photoreceptor cells. This light-triggered cascade reaction is terminated and completely restored to the dark levels by another enzymatically controlled reaction initiated by rhodopsin phosphorylation by rhodopsin kinase. Thus, phosphorylation and dephosphorylation of rhodopsin is a crucial regulatory mechanism of photoreception of rods. I found that rhodopsin phosphorylation predominantly occurs at 334, 338 and 343 serine residues in both in vivo and in vitro. Furthermore, I also found rhodopsin phosphorylation is involved in not only the quenching phototransduction but the dark adaptation processes.

著者関連情報
© by THE BIOPHYSICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top