骨格筋アクトミオシン反応の「第三の中間体」とその役割

抄録

The low force actomyosin complex, formed prior to force generation in skeletal muscle, has characteristics distinct from those of conventional weak- or strong-binding complexes and therefore constitutes a third class of intermediate in the ATPase reaction. Its dual strain sensitivity enables the muscle to resist an externally applied stretch by isomerizing to a forcesupporting form, while reducing excessive energy consumption during shortening by limiting the number of myosin molecules which enter the force-generating event.