ランタノイドイオンのアミノ酸受容体チャネルへの作用-このイオンは特異的に認識されるか?

抄録

Lanthanoides are known to affect a variety of membrane phenomena; for example, an inhibition of voltage-dependent Ca²⁺ channels. Recent studies have revealed that each of aminoacid receptor-channels is affected in its activation by La³⁺ in a different manner. La³⁺ inhibits kainate and NMDA receptor-channel responses while potentiating AMPA, GABAA, GABAC and glycine receptor-channel responses. A positive modulation by La³⁺ of GABAA receptorchannels on rat septal cholinergic neurons in culture is shared by other lanthanoide ions and Y³⁺ but not by Sc³⁺, all of which belong to the same group (III a) in the periodic table. It is suggested that there may be a specific site for binding of lanthanoides on GABAA receptorchannels.