Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice

Shuzo ORIKASA; Kazumi NABESHIMA; Noriyuki IWABUCHI; Jin-Zhong XIAO

doi:10.12938/bmfh.2016-004

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Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice

Shuzo ORIKASA, Kazumi NABESHIMA, Noriyuki IWABUCHI, Jin-Zhong XIAO

著者情報

キーワード: Bifidobacterium longum BB536, schizophrenia, rearing behavior, apomorphine, corticosterone, tryptophan, kynurenine

ジャーナルフリー早期公開

論文ID: 2016-004

DOI https://doi.org/10.12938/bmfh.2016-004

この記事には本公開記事があります。

The final version of this article is now available: Vol. 35 (2016), No. 3 pp. 141-145

詳細

抄録

Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (10⁹ CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia.

責任著者(Corresponding author)

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