Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Circumvention of Acquired Resistance to Doxorubicin in K562 Human Leukemia Cells by Oxatomide
Masaaki ISHIKAWARyousuke FUJITAShinobu FURUSAWAMotoaki TAKAYANAGIKen-ichi SASAKISusumu SATOH
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2001 Volume 24 Issue 10 Pages 1185-1187

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Abstract

We studied the effect of oxatomide, an antiallergic drug, on the resistance of K562 cells to doxorubicin. Oxatomide synergistically potentiated the cytotoxicity of doxorubicin in doxorubicin-resistant K562 cells (K562/DXR) at a concentration of 1—10 μM, but had hardly any synergistic effect on the parental cell line (K562) at the same concentration. Oxatomide inhibit P-glycoprotein pump-efflux activity and the binding of [3H]-azidopine to the cell-surface protein P-glycoprotein, in a dose-related manner. These results indicate that oxatomide reverses the multidrug-resistance phenotype through direct interaction with P-glycoprotein.

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© 2001 The Pharmaceutical Society of Japan
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