Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Calcium Signals in Rat Basophilic Leukemia (RBL-2H3) Cells Primed with the Neuropeptide Substance P
Yoko FURUKAWATadahide FURUNOReiko TESHIMAMamoru NAKANISHI
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2001 Volume 24 Issue 9 Pages 1060-1063

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Abstract

Communication between nerves and mast cells is a prototypic demonstration of neuroimmune interaction. We have recently shown that direct nerve-mast cell cross-talk can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P is an important mediator of this communication. Here we study the calcium signals in rat basophilic leukemia cells (RBL-2H3; mucosal-type mast cells) primed with substance P. RBL cells responded only slightly to stimulation with compound 48/80, however they responded to the stimulation when the cells had been primed with substance P (0.5 μM) for one week. The present results provide a foundation to study the neuroimmune cross-talk in a co-culture system.

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© 2001 The Pharmaceutical Society of Japan
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