The Effect of Ascorbic Acid and Ethanol on the Level of Thiobarbituric Acid Reactive Substances (TBARS) in Selected Tissues of Albino BALB/c Mice

Abstract

The aim of the paper was to study the effect of ascorbic acid (vitamin C) and ethanol on the level of thiobarbituric acid reactive substances (TBARS) in the brain, liver, lungs and blood serum of inbred albino BALB/c mice. Sixty male mice divided into 4 groups were used for the study; the mice in each group were injected intraperitoneally (i.p.): Group 1 - control, saline; Group 2 - H₂O₂ and FeSO₄; Group 3 - ascorbic acid (AA); Group 4 - AA and ethanol. The level of TBARS in the investigated tissues of the mice in all of the groups was statistically significant higher than in the control group. The highest content of TBARS in blood serum, brain, liver and lung tissue was observed in mice which were given ascorbic acid and ethanol.