Biological and Pharmaceutical Bulletin
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Effect of Restraint and Footshock Stress and Norepinephrine Treatment on Gastric Emptying in Rats
Fumitake TsukadaYoko NaguraShinya AbeNaoko SatoYasuhito Ohkubo
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Volume 26 (2003) Issue 3 Pages 368-370

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Abstract

We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. β3-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while β1-, β2-, α1-, and α2-adrenergic antagonists did not affect the inhibition. Norepinephrine treatment also inhibited gastric emptying. The inhibition by norepinephrine treatment was canceled by β1-, β2-, and β3-adrenergic antagonists, but not by α1- and α2-adrenergic antagonists. On the other hand, footshock stress did not affect gastric emptying. These results suggest that β3-adrenoceptors play an important role in the inhibition of gastric emptying caused by restraint stress, while nonspecific β-adrenoceptors are involved in that caused by norepinephrine treatment.

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© 2003 The Pharmaceutical Society of Japan
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