Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Serotonin Depletion Enhances the Intracerebroventricularly Administered MK-801-Induced Plasma Interleukin-6 Levels in Mice
Do-Hoon KimJun-Sub JungYoo-Sun MoonHong-Won SuhDong-Keun Song
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2003 年 26 巻 4 号 p. 547-549

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To investigate the effect of serotonin depletion on the intracerebroventricularly (i.c.v.) administered MK-801-induced plasma interleukin-6 (IL-6) levels, we pretreated mice with parachlorophenylalanine (PCPA, 300 mg/kg, i.p.) 3 d before an i.c.v. injection of MK-801 (1 μg). The i.c.v. MK-801-induced rise of plasma IL-6 level was markedly enhanced in the PCPA-pretreated mice. However, serotonin depletion by PCPA pretreatment did not affect the i.c.v. MK-801-induced increase in plasma corticosterone level. These results suggest that serotonergic system is involved in the suppressive regulation of MK-801-induced plasma IL-6 level.

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© 2003 The Pharmaceutical Society of Japan
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