Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Antioxidant Evaluations of Novel N-H and N-Substituted Indole Esters
Süreyya ÖlgenTülay Çoban
Author information
JOURNALS FREE ACCESS

2003 Volume 26 Issue 5 Pages 736-738

Details
Abstract

The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted indole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10−4 M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound α-tocopherol (vitamin E).

Information related to the author
© 2003 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top