Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents
Hideaki MatsudaYoshiko KawaguchiMiho YamazakiNoriko HirataShunsuke NarutoYusuke AsanumaTakayuki KaihatsuMichinori Kubo
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2004 Volume 27 Issue 10 Pages 1611-1616

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Abstract

A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (−)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.

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© 2004 The Pharmaceutical Society of Japan
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